ρ-Coumaric Acid

Basic Information:

Synonyms: 4-Hydrocinnamic acid

CAS: 501-98-4

Molecular Formula: C9H8O3

Molecular Weight: 164.16

Properties: White crystal; slightly soluble in water, soluble in ethanol and ether.

A NATURAL ANTIOXIDANT and antimicrobial agent;

ρ-Coumaric Acid is a naturally occurring polyphenol found in wine, vinegar, honey, tomatoes, basil, garlic and fruits.

ρ-Coumaric Acid is a potent antioxidant that can inhibit lipid peroxidation and radical scavenging as well as an effective antimicrobial agent against E. coliand S. aureus. When applied in cosmetic products, it also has skin lightening effect.

Effect:

① A polyphenolic antioxidant naturally present in plants, acting as a tyrosinase inhibitor to reduce melanin

② Anti-UV and antibacterial effects

③ Raw material for chemical synthesis

Applications:

① Food and cosmetics preservatives

② Antioxidant and whitening ingredient in cosmetics

③ Raw material for the synthesis of PHS, Esmolol, etc

Antioxidant:

ρ-Coumaric Acid has radical scavenging abiity in DPPH and ABTS experiments.

Shen Y, Song X, Li L, et al. Protective effects ofρ-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation[J]. Biomedicine & Pharmacotherapy, 2019

(A) DPPH-radical scavenging activities of ρ-CA (positive control – Trolox). (B) ABTS-radical scavenging activities ofρ-CA (positive control – Trolox).(C) Ferric ion reducing ability of plasma (FRAP) assay ofρ-CA (positive control – Trolox). (D) Metal-ion chelating ablity assay ofρ-CA (positive control – EDTA).

Antimicrobial:

ρ-Coumaric Acid shows a good ability to inhibit the growth of various microbes.

The minimal inhibitory concentrations (MIC) ofρ-coumaric acid

Lou Z, Wang H, Rao S, et al. ρ-Coumaric Acid kills bacteria through dual damage mechanisms[J]. Food

Control, 2012, 25(2):550-554

The ρ-Coumaric Acid was tested for antibacterial potential against Gram-positive (S. pneumoniae ATCC49619,B. subtilis 9372,S. aureus 6538) and Gram-negative bacteria (S. dysenteriae 51302,E. coilATCC25922, Salmonella typhimurium 50013). The MIC values for ρ-Coumaric Acid are shown in the table above. A comparison of the sensitivities of the bacterial strains toρ-coumaric acid indicated that the strongest inhibitory effect was againstS. dysentenae. ρ-Coumaric Acid showed MIC value of 10μg/ml in the case ofS. dysenteniae.

Anti-Melanogenic:

ρ-Coumaric Acid has the optimal structure to be a compettive inhibitor of tyrosinase that catalyzes key reactions in the melanin biosynthetic pathway, thus it has good potential to be used as a skin-lightening active ingredient in cosmetics.

Yong Chool Boo, ρ-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects[J]. Antioxidants 2019, 8, 275

ρ-Coumaric acid can attenuate skin hyperpigmentation through multiple mechanisms. UV and other pathophysiological conditions stimulate the production of reactive oxygen species (ROS) and multiple signaling pathways leading to enhanced gene expression of tyrosinase and increased melanin synthesis. The melanin can absorb ultraviolet (UV) radiation and alleviate oxidative stress and inflammatory reactions caused by UV radiation, but the melanin deposition may cause skin pigmentation disorders.ρ-Coumaric acid has a chemical structure similar to L-tyrosine and inhibits the activity of tyrosinase, which catalyzes the oxidation of L-tyrosine and/or L-DOPA to L-DOPA quinone in the melanin biosynthetic pathway. Due to its UV absorption and antioxidant action,ρ-coumanic acid can inhibit the signaling pathways linked to gene expression of tyrosinase and infiammatory mediators.ρ-Coumaric acid can also reduce the stimulatory effects of hormones and L-tyrosine on the gene expression of tyrosinase. Thus, it is proposed thatρ-coumaric acid has advantageous biochemical properties suitable for use as a skin-lightening active ingredient in cosmetics.

Why Choose Viablifeρ-Coumaric Acid:

Viablife producesρ-Coumaric Acid using a leading fermentation process.

Ourρ-Coumaric Acid has the highest purity so far (>99%).

Compatible with clean label and GMO-free.

https://www.viablife.net/product/nutraceuticals_food_additives/p_coumaric_acid.html